Arsenal were without seven members of their first-team squad for the Premier League opener against Liverpool on 14 August, succumbing to a 4-3 home defeat after Jürgen Klopp' s side struck three times in 14 minutes in a scintillating start to the second-half.
With both Per Mertsacker and Gabriel ruled out injured, Koscielny was also left out of the match-day squad having only just returned to training after a lengthy summer break following France's Euro 2016 campaign.
Giroud and Ozil also only returned to training a week before the start of the Premier League season and were not considered for selection, having taken no part in pre-season.
With Aaron Ramsey and Alex Iwobi also picking up knocks in the defeat to Liverpool, Gunners fans will have been hopeful of seeing the trio return to first-team action on Saturday for the trip away to the King Power Stadium.
Wenger admits that may not be the case, however. When asked whether he will risk the the players against the Foxes, he told reporters: "We will try, but when they have not enough preparation they get injured."
Wenger admitted his side were not physically ready for their first game of the season, with their problems compounded by injuries to Ramsey and Iwobi. The club now faces an anxious wait to discover the extent of the Welshman's injury.
"It's a hamstring. I don't know [how bad it is], I haven't spoken to the medical people."
While Jack Wilshere recovered from a knee injury to make the bench on Sunday, Arsenal were still without Mertesacker, Gabriel, Koscielny, Mertesacker, Ozil, Giroud Carl Jenkinson and Danny Welbeck.