Clarifying what he meant by the Dark Souls story coming to a close, director Hidetaka Miyazaki (not to confused with the director of Spirited Away) explained that Dark Souls 3 will be a turning point for the series and possibly From Software as a whole.
Speaking at a round table conference at E3 (via VideoGamer) Miyazaki responded to Namco Bandai's vice president of marketing, Herve Hoedt, who described Dark Souls 3 as the "final chapter", something which many inferred to mean the series would be coming to an end.
Expanding on the possible future of the series, Miyazaki said via translator Atsuo Yoshimura that "From software is known for other genres such as science fiction and Ninja games. So it's possible that Miyazaki may want to explore those themes in future titles."
For now though it's too early to say which direction Dark Souls will take. Despite both Bloodborne and Dark Souls 3 sharing gameplay style and world view, only Miyazaki along with some visual designers are working on both series.
Miyazaki returns as lead director of Dark Souls 3 assisted by Steel Battallion: Heavy Armour director Isamu Okono. Dark Souls 2 director Yui Tanimura will also be joining the team in some capacity.
Dark Souls 3 is expected to be released on Xbox One, PlayStation 4 and PC sometime in early 2016