Ottawa-born John Maguire is the latest Canadian jihadist to have died while fighting for Isis (Islamic State) in Syria, according to reports.

The former University of Ottawa student, who appeared in an Isis video threatening retaliation against his home country for taking part in US-led airstrikes against the Islamist group, was killed in the border town of Kobani, according to a pro-Isis Twitter account.

Three other Canadians, two brothers from Calgary and three members of an Edmonton-based ethnic Somali family, have also died in recent months while fighting for the Islamic State in Syria. It is believed that all six men died in American airstrikes.

"Any individual who decides to join the ISIS jihadists runs the risk of meeting their ultimate demise," said Jean-Christophe deleRue, spokesman for Canadian Public Safety Minister Steven Blaney.

In the propaganda video, Maguire, who called himself Abu Anwar al-Canadi, praised two separate Islamist attacks in Montreal and Ottawa that resulted in the deaths of two Canadian servicemen last October.

He also called on Canadian Muslims to launch more attacks or travel to Isis-held areas in the Middle East to join fighting.

"You either pack your bags, or prepare your explosive devices. You either purchase your airline ticket, or you sharpen your knife," he said, adding that "waging jihad" against the Western countries was "a religious obligation binding upon every Muslim."

The 23-year-old was born in Kemptville, Ontario and moved to the capital in his high-school years. He converted to Islam and drifted towards radicalism while attending university, friends told CBC News.

In the video, Maguire talked of his past as a "typical Canadian" who loved music and hockey, in an attempt to lure more of his countrymen to jihad by normalising it.

"I grew up on the hockey rink and spent my teenage years on stage playing guitar," he said.

"I had no criminal record. I was a bright student and maintained a strong GPA in university. So how could one of your people end up in my place? The answer is that we have accepted the true call of the prophets and messengers of God."

In October Canada was shocked by two deadly attacks carried out by Isis sympathisers, Martin Couture-Rouleau and Michael Zehaf-Bibeau.

Rouleau was shot dead by police after running down two soldiers, killing one, with his car near Montreal.

A few days later Zehaf-Bibeau shot and killed a soldier at a war memorial in Ottawa, before firing shots inside the Canadian parliament. He was also killed by authorities.