Sane, a £37m (€42.8m) signing from Schalke, trained with the first team following the international break this week, having recovered from a hamstring injury he arrived at the club with.
Pep Guardiola's side have gotten off to a 100% winning start in both the Premier League and their Champions League play-off, but the Germany international is hoping to muscle his way into the starting XI for the club's biggest game of the season so far.
"I feel good now and I think I am ready to play," he told City's official website. "I've trained well and my hamstring is fine so I am looking forward to finally getting started."
The first Manchester derby of the season also sees Jose Mourinho and Guardiola renew hostilities, having waged war against each other during their spells in charge of Real Madrid and Barcelona respectively.
"I've played in derby games in Germany but this should be a great match and one I'm really looking forward to, especially because Pep Guardiola is taking on Jose Mourinho."
Despite his tender years, Sane has already tasted an intense derby experience having featured in the Revierderby between Schalke and Borussia Dortmund – where he squared off against new City teammate Ilkay Gundogan.
"It should be a special game and we can sense the expectation all around the city from our supporters. I can't believe how close the two clubs are and it is maybe ten minutes to drive from City to United. In Germany it was about 30 minutes between Schalke and Dortmund but Manchester is different.
"It goes without saying that everyone wants to win this game, particularly so early in the season and both sets of supporters will be afraid of losing, but that is normal for any derby – nobody wants to end on the losing team."