Arsenal will be hoping they can repeat the stunning comeback recorded by Spanish club Deportivo La Coruna, who managed to overturn a 1-4 deficit (curiously, also against AC Milan), when the Gunners face the Italians in the second leg of their Round of 16 Champions League tie on Tuesday.
Arsene Wenger will certainly be hoping for that and feels his team can achieve the impossible, despite the statistics being against them.
"Statistically we have a five per cent chance. If you look at the history of results, it will be around that. I don't live in a dream world. I know it's not an easy situation we have created. What is important is that we believe," the Daily Mail quotes Wenger as saying.
"I see a lot of scepticism, so it is important we do not share that scepticism and show we have enough belief to make what looks impossible, possible," he added.
"Sometimes when you've made a big score the difficulty is psychological. You just need to turn up and make sure you defend well but the other team has nothing to lose so they just go for it," he further added.
Arsenal need to score five goals to progress (four, to force extra time and then penalties), without allowing the opposition to score. Wenger has confirmed he needs to change his tactics in order to achieve this impossible turnaround.
"I am tempted. At the moment, basically I have only two midfielders, [Alex] Song and [Tomas] Rosicky. That means we have to play with four strikers. We can play any system you can imagine until tomorrow night. But I will not tell you that now," Arsenal.com quoted the Frenchman as saying.
"I am tempted [to play Oxlade-Chamberlain down the middle], we will see. I have 24 hours and I have to see if Rosicky is available or not. If he is not available then I will be in a very difficult situation, because I don't know what I can do then," he added.
Wenger, whose team is plagued with many injuries, went on to say he could have "no choice" but "take a risk" by playing six strikers, including Chamakh, Park, van Persie, Gervinho, Walcott and Oxlade-Chamberlain.
Only time will tell whether Arsenal will make one their greatest comebacks ever or be humbled again by the likes of Robinho and Ibrahimovic.