Nadal has had serious knee injuries during the course of his career.
Djokovic will take on Gilles Simon in the second round of the Monte-Carlo Masters on 18 April.
Edmund triumphed in the all-British clash in straight sets.
Federer has made his best start to a season since 2006, winning three of the four tournaments entered.
Serbian is over elbow injury as clay court season starts at Monte Carlo masters.
Murray is set to return to action at the Monte-Carlo Masters.
Federer had previously revealed that he would take a 10-week break before playing in Roland Garros.
Roger Federer has won three of the four tournaments he has played in 2017.
World number one will face either Gilles Müller or wildcard Tommy Robredo following first-round bye.
Federer has already won the 2017 Australian Open, where he defeated Nadal in the final.
Nadal will be among the favourites to win the 2017 Monte Carlo Masters.
Sharapova says it is not correct for fellow professionals to keep criticising her.
Murray has returned to action after recovering from an elbow injury.
Nadal is aiming to make it 10 titles at the Monte Carlo Masters.
The 35-year-old plans to rest up ahead of the French Open.
Federer has committed to playing at his home ATP tournament in Basel at least until 2019.
Federer has risen from world number 17 to world number four in less than three months.
Spain crashed out of the competition after defeat to Serbia at the quarter-final stage.
World number one lost 3-6, 6-7 to 18-time Grand Slam champion at Zurich's Hallenstadion.
Federer has won three titles in 2017 and lost just once in his last 20 matches.
Federer has made his best start to a season since 2006 capturing three titles thus far.
World number one targets French Open return but still unable to serve properly.
Former French Open champion discusses Federer's renaissance and Rafael Nadal's clay campaign.
Kyrgios helped Australia advance to the semi-final of the Davis Cup.
With 91 career singles titles, Federer is behind Ivan Lendl (94) and Jimmy Connors (109) in the all-time list.
Great Britain eliminated after 4-1 defeat to Yannick Noah's team in Rouen.
Djokovic has defeated Nadal in their last three meetings on clay.
Jamie Murray and Dominic Inglot lose in four sets to Nicolas Mahut and Julien Benneteau in Rouen.
Sharapova will return from her doping ban at the end of April.
Federer has beaten Nadal four times in a row for the first time in his career.