McKittrick will be replaced by chief operating officer Peter Brooks-Johnson in May.
Bookmaker was hit by unfavourable results at the Cheltenham Festival in March.
The bank's total losses since 2008 now amount to about £58bn, topping the government's £45.5bn bail-out.
International publishing giant reports 8% fall in sales for 2016.
The facility will manufacture high-tech components for Boeing's Next-Generation 737, 737 MAX and 777 aircraft.
After donating hundreds of thousands of dollars into his campaign, they are seeing quick results.
One in four properties in England and Wales off-limits to prospective buyers.
High street retailer will chop approximately 800 positions in its restaurants and home fittings services.
US banking giant reportedly in talks to move jobs to Frankfurt or Dublin once Britain leaves the EU.
Money managers' survey conducted by global ratings agency deems populism as the biggest threat to economic progress in Europe.
Dr Carsten Stöcker of the innogy Innovation Hub explores IOTA for the machine economy.
Citi Tech for Integrity Challenge (T4I) gathered AML experts discuss how regtech can fight financial crime.
British Gas owner reports decline in revenue as profits from its UK home business slump.
The general insurer said it was buoyed by strong performances in the UK and Scandinavia.
Tobacco giant aims to double the number of markets for its vaping products over the next two years.
Profit before tax advanced 5.6% to £1.15bn in 2016.
Travel group announces net profit of £170m for 2016 calendar year.
The bank saw sales its powerhouse credit card business jump 21% to £4bn.
There is a growing mismatch between the number of jobs available and number of people seeking jobs.
Vauxhall employs more than 4,000 people across its plants at Ellesmere Port and Luton.
Companies are looking to maintain access to single market, even as Britain loses it.
New guidance overrides previous advice that dryers could be used if watched at all times.
RavenPack will be at the Newsweek conference on AI and Data Science in Capital Markets in London.
Interview: Liberal Democrat leader spoke to IBTimes UK at launch of new green technology drive.
Official tells International Petroleum Week it is unclear whether six months of cuts would be "enough or not".
The new man will take the top job at a time time of great change in the defence industry.
The blockchain prototype, done together with trading house Mercuria, coincided with IP Week in London.
Challenger bank moves step closer to climbing out of red as underlying loss narrows from £46.6m to £11.7m.
Author, investor and Ethereum advisor William Mougayar is a long-time champion of decentralisation.
UK economy grew 0.7% in final quarter of 2016, but expanded 2% on a yearly basis, down from 2.2% estimate.