Disney has been looking at ways to revive the franchise with stories from new talent as well as new female-fronted films.
During a chat with Conan, the Oscar winner said his plate was full with villainous roles – "four of the most notorious bad guys" – after the success of 2016 release Suicide Squad.
Batman and Harley Quinn join forces to fight Poison Ivy: Here's every detail from DC's new animation
The team-up is interesting for DC fans considering Quinn's long-standing romance with Ivy.
Suicide Squad spin-off is set to be directed by David Ayer and will star Margot Robbie as DC Comics' Harley Quinn.
It had previously been stated the studio would only shoot standalone film Aquaman this year.
Haley Bennett as Catwoman: Is The Girl On The Train star teasing casting in cryptic Instagram posts?
Fans are speculating that Bennett could appear alongside Margot Robbie in Warner Bros' Gotham City Sirens.
Suicide Squad director David Ayer is looking to helm the supervillain movie, based on the recent DC Comics' series.
What the Queen of Gotham City did next – Margot Robbie and Warner Bros map out Harley Quinn spin-off
Suicide Squad actress, who will work under her LuckyChap Entertainment banner, already has two projects in pipeline..
Amanda Waller introduced Deadshot back in season two, while fans caught a glimpse of Harley Quinn as well.
DC super-villains added to NetherRealm Studios' sequel with designs inspired by David Ayer's 2016 movie.
A handful of good performances can't overcome messy plotting, an obnoxious soundtrack and terrible villains.
A psychiatrist-turned-psycho and the clown prince of crime in blockbuster are explained...
Harley Quinn actress reveals hardcore behind-the-scenes preparation on The Tonight Show.
San Diego-based convention officially kicked off on Wednesday 20 July with a preview night
We've already seen him causing chaos in the trailers but why is he going up against the 'Worst Heroes Ever'?
Suicide Squad: New character photos of Jared Leto's Joker and other members of the supervillain team released
The film will open in the US on 5 August.
Suicide Squad actresses tease their characters Harley Quinn, Enchantress, Amanda Weller in the movie.
Fans attended a free viewing of the DC film in California this weekend... and they were pleased with what they saw.
Harley Quinn is the psychotic doctor in Suicide Squad, who shares a violent relationship with the Joker.
The Suicide Squad actress opened up about Hollywood labels in an interview with Woman's Day.
...Not to mention, we're also introduced to the Joker's fantastically bold fashion choices.
Following Batman v Superman's dark tones, the studio has decided cinema-goers need more laughs.
Suicide Squad producer Charles Roven addresses the film's PG-13 rating.
There's skulls and colours galore in the first posters for the DC film, concentrating on individual villains.
Warner Bros Pictures also released a brand new image of the gang looking ready for action.
The Focus actress also opened up about what it was like to work with Will Smith for a second time.
Suicide Squad second trailer update: Alleged description leaks online and teases a big Joker and Harley Quinn scene
Suicide Squad second trailer is expected to release in January 2016.
Marvel character Harley Quinn tops Google trends as most searched Halloween costume of 2015.
'Deadshot's eyeballing her a little bit,' the 47-year-old said of his on-screen character.
Will Smith teases Jared Leto's "method" approach to playing Joker.