What Is Project Artichoke? CIA Revives Files Detailing Covert Drug Plans In Food, Drink And Vaccines
Declassified documents show early CIA programme considered using substances and techniques to influence behaviour without consent

The CIA has republished declassified documents relating to Project Artichoke, a top-secret Cold War programme that explored mind control, behaviour modification, and advanced interrogation techniques. The files detail proposals to administer chemicals covertly through food, drinks, cigarettes and even medical treatments such as vaccines or injections in an effort to influence human behaviour.
The release has ignited debate about the extent to which intelligence agencies pursued psychological manipulation during the early Cold War. Analysts suggest the documents highlight both the ambitious and ethical shortcomings of secretive research conducted in the name of national security.
CIA Explored Methods To Manipulate Behaviour
Project Artichoke, which operated between 1951 and 1956, focused on the development and testing of substances intended to influence and manipulate human mental states. The CIA documents indicate that researchers sought compounds capable of producing a range of psychological effects. Some were designed to create agitation, anxiety, or nervousness, potentially making individuals more susceptible to suggestion.
Others were intended to induce depression, lethargy, or despondency, effectively dulling resistance and impairing decision-making. The programme also explored the use of sedatives such as amytal and pentothal, commonly described at the time as 'truth serums', with the aim of compelling individuals to divulge information or act against their own interests.
To administer these substances covertly, Project Artichoke researchers considered a variety of delivery methods. Proposals included slipping chemicals into food and water, contaminating beverages such as alcohol or soft drinks, and using cigarettes.
The documents even suggested disguising compounds in medical treatments, including injections and vaccinations, to reach targets without their knowledge. Beyond chemical approaches, the programme investigated psychological and physiological techniques to manipulate behaviour. Methods included hypnosis, sensory deprivation, exposure to gases and aerosols, and controlled oxygen reduction, all designed to weaken resistance and influence compliance.
Project Artichoke Preceded MKUltra
The programme is recognised as a precursor to the more expansive MKUltra initiative, which began in 1953. MKUltra extended similar research, incorporating hallucinogenic drugs and hundreds of subprojects to investigate mind-altering methods.
A seven-page CIA report titled 'Special Research for Artichoke' outlined plans to influence behaviour and conduct psychological manipulation, reflecting fears of communist brainwashing during the early Cold War. Ethical oversight was minimal, and many experiments were proposed for unconsenting subjects. Some former participants, including prisoners, later reported experiencing severe psychological effects such as paranoia and hallucinations.
Public Reaction And Oversight
Project Artichoke was first revealed publicly in the 1970s during congressional hearings conducted by the Church Commission. The disclosures prompted widespread concern over ethical violations in intelligence operations and led to reforms in oversight procedures.
The recent release of these documents has renewed discussion about historical government experimentation on human subjects. Analysts have noted that the programme illustrates the potential risks of secretive operations that combine scientific research with national security objectives.
Legacy And Contemporary Relevance
Project Artichoke remains significant as an example of early psychological research conducted under the auspices of national security. Its methods, ranging from chemical compounds to advanced interrogation techniques, demonstrate the extent to which intelligence agencies pursued control over human behaviour.
While largely historical, the programme's legacy is evident in discussions surrounding MKUltra and modern ethical standards for human experimentation. The CIA's republished files serve as a reminder of the challenges of balancing security, scientific research, and human rights, and the need for transparency and oversight in intelligence operations.
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